Journal of Peritoneum (and other serosal surfaces) <p>The <strong>Journal of Peritoneum (<em>and other serosal surfaces</em>)</strong> (JoPER) is a quarterly open access, peer-reviewed online journal that covers all aspects of clinical and basic research related to either healthy, either diseased peritoneum (and other serosal surfaces, like pericardium and pleura) and its allied subjects. Peritoneum is a word derived from Greek (peritonaion) via Latin (peritonaeum), that results from the merging of peri- "around" (lat. peri-) + teinein "to stretch" (lat. tenet), meaning thus “stretched around” or “stretched over”. Although peritoneum is present in some invertebrates, such as annelids, typically is the serous membrane that forms the internal covering of the abdominal cavity or coelom in amniotes, wrapping most of the intra-abdominal (or coelomic) organs. Although the peritoneum is composed only of a layer of mesothelium supported by a thin stratum of connective tissue, it is involved in many intrabdominal disorders and is an important way of treatment (like, for example, intraperitoneal chemotherapy and peritoneal dialysis). Thus peritoneum spans a wide range of disciplines and interests, including either surgical and medical specialties, but even anatomy, embryology, histology, physiology and basic sciences. The same can be told for other serosal surfaces of human body, like pericardium and pleura. As such JoPER aims to provide a platform for surgeons and physicians to publish their researches and rapidly exchange ideas and findings with the common topic of the peritoneum (and the other serosal surfaces). Areas of interest include, but are not limited to: oncology, inflammatory diseases and adhesions, septic diseases, gynecological diseases and endometriosis. The online presence of JoPER, as well as it's open access policy ensures that the articles published in the journal are highly visible and reach a wide audience, whilst immediate publication on acceptance ensures all findings are disseminated as quickly as possible.</p> PAGEPress Scientific Publications, Pavia, Italy en-US Journal of Peritoneum (and other serosal surfaces) 2531-4270 <p><strong>PAGEPress</strong> has chosen to apply the&nbsp;<a href="" target="_blank" rel="noopener"><strong>Creative Commons Attribution NonCommercial 4.0 International License</strong></a>&nbsp;(CC BY-NC 4.0) to all manuscripts to be published.<br><br> An Open Access Publication is one that meets the following two conditions:</p> <ol> <li>the author(s) and copyright holder(s) grant(s) to all users a free, irrevocable, worldwide, perpetual right of access to, and a license to copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship, as well as the right to make small numbers of printed copies for their personal use.</li> <li>a complete version of the work and all supplemental materials, including a copy of the permission as stated above, in a suitable standard electronic format is deposited immediately upon initial publication in at least one online repository that is supported by an academic institution, scholarly society, government agency, or other well-established organization that seeks to enable open access, unrestricted distribution, interoperability, and long-term archiving.</li> </ol> <p>Authors who publish with this journal agree to the following terms:</p> <ol> <li>Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.</li> <li>Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.</li> <li>Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.</li> </ol> Which prognostic score for abdominal sepsis? Analysis of final results of PIPAS (Physiological Indicators for Prognosis in Abdominal Sepsis) study in a single center <p>Intra-abdominal infections (cIAIs) constitute an important cause of morbidity and mortality. Numerous risk factors may influence prognosis of cIAIs. This study aims to evaluate which parameters and scores may better predict prognostic outcomes in cIAIs. This is a single-center prospective observational study. Data from sixty-five patients were collected during a four-month period. Univariate and multivariate analysis for physiological parameters and ROC curves for SIRS, qSOFA and WISS scores were calculated in relation to mortality, intensive care unit (ICU) admission and surgical complications. Blood oxygen saturation level (SpO<sub>2</sub>), heart and respiratory rate, systolic blood pressure (SBP), level of consciousness, INR, C-reactive protein (CRP), white blood cells, source control and health care-acquired infections affect prognosis in cIAIs according to univariate analysis. On multivariate analysis level of consciousness, SpO2, CRP, diffuse peritonitis, INR and SBP significantly influenced prognosis in cIAIs. AUROC for WISS score were 0.89 for mortality, 0.86 for major complications, 0.76 for ICU admission. In our study many risk factors adversely affect prognostic outcomes in cIAIs; PIPAS study probably may provide even better results on that. Moreover, WISS score reached remarkable performance in predicting mortality and major surgical complications in abdominal sepsis; qSOFA did not achieve satisfactory results in none of analyzed outcomes.</p> Stefano Raimondo Massimo Sartelli Federico Coccolini Paola Fugazzola Raffaele Bova Matteo Tomasoni Fausto Catena Luca Ansaloni ##submission.copyrightStatement## 2018-12-19 2018-12-19 10.4081/joper.2018.106 The effect of hyperthermia (42°C) on the anti-tumoral effect of bromelain, N-acetyl cysteine, chemotherapeutic agents and their combinations - an in vitro evaluation <p>Bromelain, N-acetyl cysteine and their combinations show cytotoxicity at 37°C. Similarly, their combinations with common chemotherapeutic agents (gemcetabine, Mitomycin C, oxaliplatin and 5-FU) show enhanced cytotoxicity. Since, hyperthermia (42°C) inhibits cellular proliferation, we set out to determine if it would further enhance the effect of these agents. Tumour cells (pancreatic and colorectal) were grown in a 96 well plate and treated to various agents and their combinations at 37° and 42°C. The survival of cells at 72 hours was evaluated with sulfhordamine assay. Colony formation assay was performed to evaluate development of resistance to these agents and finally PAS staining was carried out to determine the effect of bromelain, Nacetylcysteine (NAC), oxaliplatin and their combinations on mucin secretion in ASPC-1 (pancreatic) cancer cells. Hyperthermia (42°C) enhanced cytotoxicity of certain agents or their combinations in some of the cell lines. It also showed the absence or a reduction of effect, with certain agents. Hyperthermia reduced colony formation in CFPAC cells and with agents (bromelain + NAC, gemcitabine, NAC + gemcitabine, Bromelain + NAC + Gemcitabine). A similar effect with 5FU, 5FU + NAC and 5FU + bromelain was observed. Hyperthermia reduced mucin secretion in ASPC-1 cells, with bromelain and its combinations with NAC and oxaliplatin. NAC as a single agent increased mucin with hyperthermia. The effect of hyperthermia on cytotoxicity of bromelain, NAC and their combinations with chemotherapeutic agents varied with agents, their combinations and cell types, showing an increase, null effect or a decrease. However, hyperthermia reduced colony formation and mucin secretion.</p> Vanessa H.L. Wan Krishna Pillai Samina Badar Javed Akhter David L Morris ##submission.copyrightStatement## 2018-12-14 2018-12-14 10.4081/joper.2018.104 Abdominal pain and fever in a patient with familial periodic fever: an extremely rare mutation of the TNF receptor superfamily member 1A gene <p>Periodic fever syndromes (PFSs) are a clinically inhomogeneous group of diseases based on peculiar genetic mutations. PFSs have to be suspected in young patients presenting with recurrent attacks of abdominal pain, skin rashes, arthritis, myalgia and fever as soon as more prevalent diseases have been excluded. An unconsidered hypothesis of PFSs may lead in delaying the diagnosis and unnecessary medical and surgical treatments. In this article, we described the case of a young man presented to our attention due to recurrent abdominal pain and fever caused by TNF-receptor-associated periodic syndrome (TRAPS) sustained by the <em>TNFRSF1A</em> gene mutation.</p> Michele Marini Emanuele Rausa Federico Coccolini Federica Bianco Cecilia Merli Salvatore Greco Antonio Luca Brucato Lorena Mosca Alessandra Surace Sandro Sironi Luca Campanati Luca Ansaloni ##submission.copyrightStatement## 2018-08-07 2018-08-07 10.4081/joper.2018.98 Gastric cancer indocyanine green lymph node navigation surgery: systematic review <p>Sentinel lymph node (LN) biopsy is a common practice to determinate if a lymphadenectomy is needed in various malignancies. Recent studies have investigated the possibilities to extend sentinel LN biopsy in gastric cancer. Indocyanine green (ICG) is a diagnostic reagent recently introduce in sentinel LN biopsy field. This review aims to determinate the feasibility to used ICG to detect sentinel LN in gastric cancer.</p> Beatrice Molteni Paola Porsio Sarah Molfino Marie Sophie Alfano Sara Benedicenti Fausto Catena Luca Ansaloni Nazario Portolani Gianluca Baiocchi ##submission.copyrightStatement## 2018-08-07 2018-08-07 10.4081/joper.2018.97